The role of Asia’s middle powers in a new era of great-power politics defined by U.S.-China rivalry is the focus of this special issue of Asia Policy, which includes a collection of essays, guest edited by Hoo Tiang Boon and Sarah Teo, on Australia, South Korea, Indonesia, Vietnam, Thailand, and Pakistan. It also features a roundtable on whether and how minilateral groupings can provide effective deterrence and maintain stability in the Indo-Pacific and an essay on U.S.-Japan cooperation in staving off the threats confronting the rules-based economic order. It concludes with a book review roundtable on Kevin Rudd’s The Avoidable War: The Dangers of a Catastrophic Conflict between the U.S. and Xi Jinping’s China.